It has been shown that out of all dog breeds, it is the Labrador Retriever that is most likely to be obese.[73] In a 2016 published study it was shown that out of 310 Labradors, most were missing all or parts of the POMC gene. This gene plays a part in appetite regulation as well as indication of the amount of one's stored fat. The study concluded that the absence of that gene had a significant impact on Labrador weight and appetite.[70][73] The POMC gene mutation is present in only one other breed – the Flat-Coated Retriever.[70]